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Heart-specific gene silencing via single-AAV-delivered base editing [RNA-Seq]

GSE265935 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/21 Platform GPL28330
Summary
We used an adenine base editor to target the translation start site and mRNA splicing site of Camk2d in order to knock out CaMKIIδ. We found that editing the 5' splice site of intron 7 can lead to premature translation termination, effectively knocking out CaMKIIδ.
Published in
ABE-Mediated Cardiac Gene Silencing via Single AAVs Requires DNA Accessibility
Liu Z, Yang L, Yang Y et al. · Circulation research 2025 · PMID 39817340 · doi:10.1161/CIRCRESAHA.124.325611
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Also filed as BioProject PRJNA1104998 and SRA study SRP504349. Searching any of these in the dataset finder brings you back here.

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