Nrf2-mediated chromatin activation of hyperosmotic response genes attenuates heat-induced renal injury [RNA-seq]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Nrf2-mediated epigenetic priming of osmoprotective genes enhances cellular adaptation to hyperosmotic stressThe Journal of biological chemistry · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266023_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1105357 and SRA study SRP504401. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 8 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8239616 mIMCD3 cells, DMSO_1h_rep1 mIMCD3 cells, DMSO_1h
- GSM8239617 mIMCD3 cells, DMSO_1h_rep2 mIMCD3 cells, DMSO_1h
- GSM8239618 mIMCD3 cells, DMSO_6h_rep1 mIMCD3 cells, DMSO_6h
- GSM8239619 mIMCD3 cells, DMSO_6h_rep2 mIMCD3 cells, DMSO_6h
- GSM8239620 mIMCD3 cells, DMSO_Ctrl_rep1 mIMCD3 cells, DMSO_Ctrl
- GSM8239621 mIMCD3 cells, DMSO_Ctrl_rep2 mIMCD3 cells, DMSO_Ctrl
- GSM8239622 mIMCD3 cells, Nrf2KO_SFN_rep1 mIMCD3 cells, Nrf2KO_SFN
- GSM8239623 mIMCD3 cells, Nrf2KO_SFN_rep2 mIMCD3 cells, Nrf2KO_SFN
- GSM8239624 mIMCD3 cells, Nrf2KO_SFN_HS1h_rep1 mIMCD3 cells, Nrf2KO_SF…
- GSM8239625 mIMCD3 cells, Nrf2KO_SFN_HS1h_rep2 mIMCD3 cells, Nrf2KO_SF…
- GSM8239626 mIMCD3 cells, SFN_1h_rep1 mIMCD3 cells, SFN_1h
- GSM8239627 mIMCD3 cells, SFN_1h_rep2 mIMCD3 cells, SFN_1h
- GSM8239628 mIMCD3 cells, SFN_6h_rep1 mIMCD3 cells, SFN_6h
- GSM8239629 mIMCD3 cells, SFN_6h_rep2 mIMCD3 cells, SFN_6h
- GSM8239630 mIMCD3 cells, SFN_Ctrl_rep1 mIMCD3 cells, SFN_Ctrl
- GSM8239631 mIMCD3 cells, SFN_Ctrl_rep2 mIMCD3 cells, SFN_Ctrl
- GSE266024 Nrf2-mediated chromatin activation of hyperosmotic response genes attenuates heat-induced renal injury 42 samples shares nrf2-mediated, hyperosmotic, heat-induced, activation, attenuates, chromatin, injury
- GSE266022 Nrf2-mediated chromatin activation of hyperosmotic response genes attenuates heat-induced renal injury [ChIP-seq] 24 samples shares nrf2-mediated, hyperosmotic, heat-induced, activation, attenuates, chromatin, injury
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares activation, rna-seq
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares activation, injury
- GSE276182 NF-κB activation in astrocytes critically affects wound regeneration after traumatic brain injury 51 samples shares activation, injury
- GSE296993 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation [RNA-seq of mESC] 50 samples shares activation, rna-seq
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares activation, rna-seq
- GSE333586 Formylpeptide Receptor Activation Attenuates Renovascular Remodeling in Neurogenic Hypertension (Left Ventricle) 26 samples shares activation, attenuates
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.