GEO series
CoMtb alters the immune landscape following Mtb infection [B6 scSCRNAseq]
GSE266233
Mus musculus
Expression profiling by high throughput sequencing
44 samples
2024/06/18
GPL24247
Summary
To characterize the influence of CoMtb on immune responses during infection, we performed single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected C57Bl/6 mice with and without CoMtb immediately pre-infection and at 10, 17 and 34 days after conventional dose (50-100 CFU) Mtb infection. We found that CoMtb induces rapid recruitment and activation of T cells, macrophage, and diminished late neutrophil responses.
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