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Effects of methotrexate and tofacitinib on gene expression of activated rheumatoid arthritis fibroblast-like synoviocytes

GSE266310 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/10/04 Platform GPL18573
Summary
Activated fibroblast-like synoviocytes (FLS) are drivers of synovitis and structural joint damage in rheumatoid arthritis (RA). Despite the use of disease-modifying drugs, only about 50% of RA patients reach remission in real-world settings. We used an unbiased approach to investigate the effects of standard-of-care methotrexate (MTX) and a Janus kinase inhibitor, tofacitinib (TOFA), on gene expression in RA-FLS, in order to identify untargeted disease mediators.
Published in
Methotrexate promotes the release of granulocyte-macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling
Bergström B, Selldén T, Bollmann M et al. · Arthritis research & therapy 2024 · PMID 39394168 · doi:10.1186/s13075-024-03406-6
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Also filed as BioProject PRJNA1106544 and SRA study SRP505043. Searching any of these in the dataset finder brings you back here.

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