snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice
RNA-seq (gene expression) · human · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 11 samples: 3 × RA-FLSs cells, OE_Vecto vs 3 × RA-FLSs cells, OE_SNORD3 vs 3 × RA-FLSs cells, SH_SNORD3 vs 2 × RA-FLSs cells, SH-VectoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in miceScience translational medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309533_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1336225 and SRA study SRP629571. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9268790 RA-FLSs cells, OE_Vector_1 RA-FLSs cells, OE_Vecto
- GSM9268791 RA-FLSs cells, OE_Vector_2 RA-FLSs cells, OE_Vecto
- GSM9268792 RA-FLSs cells, OE_Vector_3 RA-FLSs cells, OE_Vecto
- GSM9268793 RA-FLSs cells, OE_SNORD3_1 RA-FLSs cells, OE_SNORD3
- GSM9268794 RA-FLSs cells, OE_SNORD3_2 RA-FLSs cells, OE_SNORD3
- GSM9268795 RA-FLSs cells, OE_SNORD3_3 RA-FLSs cells, OE_SNORD3
- GSM9268796 RA-FLSs cells, SH-Vector_1 RA-FLSs cells, SH-Vecto
- GSM9268797 RA-FLSs cells, SH-Vector_3 RA-FLSs cells, SH-Vecto
- GSM9268798 RA-FLSs cells, SH_SNORD3_1 RA-FLSs cells, SH_SNORD3
- GSM9268799 RA-FLSs cells, SH_SNORD3_2 RA-FLSs cells, SH_SNORD3
- GSM9268800 RA-FLSs cells, SH_SNORD3_3 RA-FLSs cells, SH_SNORD3
- GSE266310 Effects of methotrexate and tofacitinib on gene expression of activated rheumatoid arthritis fibroblast-like synoviocytes 9 samples shares fibroblast-like, synoviocytes, rheumatoid, arthritis
- GSE301891 RNA-Seq Analysis of Fibroblast-Like Synoviocytes Treated With Lutein in a Rheumatoid Arthritis Context 6 samples shares fibroblast-like, synoviocytes, rheumatoid, arthritis
- GSE276473 DLX4 regulates the invasiveness of Rheumatoid Arthritis Fibroblast-Like Synoviocytes and a cancer transcriptomic signature 6 samples shares fibroblast-like, synoviocytes, rheumatoid, arthritis
- GSE280445 Effect of MSMP inhibition on the gene expression profiles of rheumatoid fibroblast-like synoviocytes 6 samples shares fibroblast-like, synoviocytes, rheumatoid
- GSE276772 NUSAP1 regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Phenotypes Implicated in Joint Damage, and a cancer-associated transcriptomic signature. 6 samples shares fibroblast-like, rheumatoid, arthritis
- GSE241249 Transcriptome profile of fibroblast-like synoviocytes with FTO knockdown 6 samples shares fibroblast-like, synoviocytes
- GSE268214 Effects of NCL Knockdown on Fibroblast-Like Synoviocytes 6 samples shares fibroblast-like, synoviocytes
- GSE241254 FTO-mediated RNA m6A demethylation regulates aggressive behavior and inflammation of fibroblast-like synoviocytes 18 samples shares fibroblast-like, synoviocytes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.