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Effects of miR-15a modulation in gene expression in human aortic SMCs

GSE266337 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/16 Platform GPL24676
Summary
Among in silico predicted or experimentally confirmed miR-15a targets are many genes of relevance to AAA pathology and known to be down-regulated in AAA conditions. To better understand which of these targets could be linked to the observed detrimental effects of miR-15a on SMC dynamics in vitro, we performed RNA-sequencing of hAoSMCs transfected with miR-15a-modulators (mimic, inhibitor, and scrambled control). Upon transfection with miR-15a-mimic, 1030 genes were significantly down-regulated and 741 were significantly up-regulated, whereas miR-15a-inhibition led to 23 down-regulated and 82 up-regulated genes.
Published in
MicroRNA-15a-5p mediates abdominal aortic aneurysm progression and serves as a potential diagnostic and prognostic circulating biomarker
Winski G, Chernogubova E, Busch A et al. · Communications medicine 2025 · PMID 40481348 · doi:10.1038/s43856-025-00892-w
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Also filed as BioProject PRJNA1106784 and SRA study SRP505163. Searching any of these in the dataset finder brings you back here.

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