Role of FGF21 in cardiac hypertrophy
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 × Heart, Sham, 3 days, vs 5 × Heart, TAC, 3 days, vs 5 × Heart, Sham, 2 weeks, vs 5 × Heart, TAC, 2 weeks,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signalingCell reports. Medicine · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266368_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1106030 and SRA study SRP504694. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8245800 Heart, Sham, 3 days, rep1 Heart, Sham, 3 days,
- GSM8245801 Heart, Sham, 3 days, rep2 Heart, Sham, 3 days,
- GSM8245802 Heart, Sham, 3 days, rep3 Heart, Sham, 3 days,
- GSM8245803 Heart, Sham, 3 days, rep4 Heart, Sham, 3 days,
- GSM8245804 Heart, Sham, 3 days, rep5 Heart, Sham, 3 days,
- GSM8245805 Heart, TAC, 3 days, rep1 Heart, TAC, 3 days,
- GSM8245806 Heart, TAC, 3 days, rep2 Heart, TAC, 3 days,
- GSM8245807 Heart, TAC, 3 days, rep3 Heart, TAC, 3 days,
- GSM8245808 Heart, TAC, 3 days, rep4 Heart, TAC, 3 days,
- GSM8245809 Heart, TAC, 3 days, rep5 Heart, TAC, 3 days,
- GSM8245810 Heart, Sham, 2 weeks, rep1 Heart, Sham, 2 weeks,
- GSM8245811 Heart, Sham, 2 weeks, rep2 Heart, Sham, 2 weeks,
- GSM8245812 Heart, Sham, 2 weeks, rep3 Heart, Sham, 2 weeks,
- GSM8245813 Heart, Sham, 2 weeks, rep4 Heart, Sham, 2 weeks,
- GSM8245814 Heart, Sham, 2 weeks, rep5 Heart, Sham, 2 weeks,
- GSM8245815 Heart, TAC, 2 weeks, rep1 Heart, TAC, 2 weeks,
- GSM8245816 Heart, TAC, 2 weeks, rep2 Heart, TAC, 2 weeks,
- GSM8245817 Heart, TAC, 2 weeks, rep3 Heart, TAC, 2 weeks,
- GSM8245818 Heart, TAC, 2 weeks, rep4 Heart, TAC, 2 weeks,
- GSM8245819 Heart, TAC, 2 weeks, rep5 Heart, TAC, 2 weeks,
- GSE267618 Role of FGF21 in cardiac hypertrophyII 14 samples shares fgf21, hypertrophy, cardiac
- GSE210983 AAV9-medated cardiac expression of lncRNA CARDINAL ameliorate TAC induced hypertrophy 16 samples shares hypertrophy, cardiac
- GSE322779 Transcription factor TFEB antagonizes cardiac hypertrophy and failure by enhancing lysosomal capacity and mitochondrial function 16 samples shares hypertrophy, cardiac
- GSE261561 Contribution of VEGF-B-induced endocardial endothelial cell lineage in physiological versus pathological cardiac hypertrophy. 12 samples shares hypertrophy, cardiac
- GSE307584 Aberrant Upregulation of Histamine N-Methyltransferase Exacerbates Pathological Cardiac Hypertrophy and Heart Failure via Disruption of SAM/Frizzled-2/ CaMKII Signaling Pathway [RNA-seq] 12 samples shares hypertrophy, cardiac
- GSE315915 Exercise Metabolic Memory Halts Pathological Cardiac Hypertrophy via PDK4 10 samples shares hypertrophy, cardiac
- GSE304958 Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency 40 samples shares fgf21
- GSE255321 Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice 24 samples shares fgf21
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.