Interleukin-1β Induces Human Endothelial Surface Expression and Trans-presentation of Interleukin-15 by Relieving let-7c-3p Suppression of Protein Translation (bulk RNA-Seq)
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein TranslationJournal of immunology (Baltimore, Md. : 1950) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266372_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1106841 and SRA study SRP505232. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8245834 jj_B
- GSM8245835 jj_Ctrl
- GSM8245836 jj_G
- GSM8245837 jj_GB
- GSM8245838 jj_TNF
- GSM8245839 jm_B
- GSM8245840 jm_Ctrl
- GSM8245841 jm_G
- GSM8245842 jm_GB
- GSM8245843 jm_TNF
- GSM8245844 tm_B
- GSM8245845 tm_Ctrl
- GSM8245846 tm_G
- GSM8245847 tm_GB
- GSM8245848 tm_TNF
- GSE266374 Interleukin-1? Induces Human Endothelial Surface Expression and Trans-presentation of Interleukin-15 by Relieving let-7c-3p Suppression of Protein Translation 30 samples shares let-7c-3p, trans-presentation, interleukin-15, interleukin-1, endothelial, suppression, translation, relieving
- GSE253352 Interleukin-15-armored GPC3-CAR T cells for patients with solid cancers 83 samples shares interleukin-15, interleukin-1
- GSE289738 Effect of interleukin-1beta on confluent human lymphatic endothelial cells 6 samples shares interleukin-1, endothelial
- GSE268958 Molecular Profile of Interleukin-17RA Blockade by Brodalumab in Japanese Patients with Psoriasis: Results from the ESPRTI study 163 samples shares interleukin-1
- GSE285099 RNA sequencing of human airway epithelial cultures from cystic fibrosis (CF) and non-CF donors exposed to tumor necrosis factor-alpha and interleukin-17 (TNFα+IL-17) for 5 hours 24 samples shares interleukin-1
- GSE304063 Dual Impact of Interleukin-17A Blockade on Inflammatory and Stromal Pathways in Peripheral Spondyloarthritis 24 samples shares interleukin-1
- GSE218386 Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration [RNA-seq] 13 samples shares interleukin-1
- GSE253764 Transcriptional remodeling of human hematopoeitic stem cells in vitro by Interleukin-1β 12 samples shares interleukin-1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.