ESR1 fusions invoke breast cancer subtype-dependent enrichment of ligand independent oncogenic signatures and phenotypes [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and PhenotypesEndocrinology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266407_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1106990 and SRA study SRP505271. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8246472 ESR1-WT_shESR1_Veh_Input
- GSM8246473 ESR1-WT_shESR1_Veh
- GSM8246474 ESR1-WT_shESR1_E2_Input
- GSM8246475 ESR1-WT_shESR1_E2
- GSM8246476 ESR1-∆CTD_shESR1_Veh_Input
- GSM8246477 ESR1-∆CTD_shESR1_Veh
- GSM8246478 ESR1-DAB2_shESR1_Veh_Input
- GSM8246479 ESR1-DAB2_shESR1_Veh
- GSM8246480 ESR1-LPP_shESR1_Veh_Input
- GSM8246481 ESR1-LPP_shESR1_Veh
- GSM8246482 ESR1-SOX9_shESR1_Veh_Input
- GSM8246483 ESR1-SOX9_shESR1_Veh
- GSM8246484 ESR1-YAP1_shESR1_Veh_Input
- GSM8246485 ESR1-YAP1_shESR1_Veh
- GSE310412 Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor- and stem-like cell expansion in the context of ESR1 mutation 24 samples shares esr1, phenotypes
- GSE310672 Progesterone receptors drive advanced breast cancer phenotypes including circulating tumor- and stem-like cell expansion in the context of ESR1 mutation [RNA-seq] 48 samples shares esr1, phenotypes
- GSE301284 KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival [ChIP-Seq] 46 samples shares independent, chip-seq
- GSE309491 Independent cell type-specific expression and distal regulation of the 9p21 locus cell cycle regulators: p14ARF, p16INK4A, p15INK4A, and ANRIL [ChIP-seq] 9 samples shares independent, chip-seq
- GSE282665 Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB 93 samples shares independent, phenotypes
- GSE267459 Megacomplex protects ESR1 from degradation by Fulvestrant in epithelial ovarian cancer 16 samples shares esr1
- GSE295510 Deciphering ESR1-driven transcription in human endometrial stromal cells via transcriptome, cistrome, and integration with chromatin landscape [ESR1_Cut_Run] 13 samples shares esr1
- GSE255767 MCF-7 ESR1 drug response 70 samples shares esr1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.