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Gene expression profile at single cell level of primary regulatory T cells(CD25+CD127- Treg), primary induced regulatory T cells(iTreg), and AMRT treated iPSC-derived CD4+ T cells (iCD4+Treg-like)

GSE266541 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/06/16 Platform GPL24676
Summary
We used single cell RNA sequencing (scRNA-seq) to analyze the difference among CD25+CD127-Treg, iTreg, and iCD4+Treg-like. We expanded CD25+CD127-Treg by TCR stimulation in the presense of AS2863619, anti-TNFR2 antibody, and TGFbeta (AMT). We differentiated iTreg from naive CD4+T cells and iCD4+Treg-like from iPSC-derived CD4+T cells in the presence of TCR stimulation, AS2863619, anti-TNFR2 antibody, TGFbeta, and rapamycin (AMRT).
Published in
Human iPSC-derived CD4(+) Treg-like cells engineered with chimeric antigen receptors control GvHD in a xenograft model
Yano H, Koga K, Sato T et al. · Cell stem cell 2024 · PMID 38848686 · doi:10.1016/j.stem.2024.05.004
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Also filed as BioProject PRJNA1107552 and SRA study SRP505580. Searching any of these in the dataset finder brings you back here.

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