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A high-resolution map of active promoters in the human genome

GSE2672 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 49 samples Submitted 2005/06/29 Platform GPL2068Platform GPL2071Platform GPL2088Platform GPL2060Platform GPL2077Platform GPL2080Platform GPL2054Platform GPL2074Platform GPL2057Platform GPL2086Platform GPL2083Platform GPL2063Platform GPL2066Platform GPL2069Platform GPL2052Platform GPL2089Platform GPL2072Platform GPL2055Platform GPL2075Platform GPL2078Platform GPL2058Platform GPL2061Platform GPL2081Platform GPL2087Platform GPL2090Platform GPL2070Platform GPL2064Platform GPL2067Platform GPL2084Platform GPL570Platform GPL2053Platform GPL2076Platform GPL2073Platform GPL2056Platform GPL2059Platform GPL2079Platform GPL2062Platform GPL2560Platform GPL2082Platform GPL2085Platform GPL2065
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 49 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
49 samples
Data you can get
A processed expression table (series matrix) and the array files, from NCBI.
Summary (written by the submitters)
Our ability to understand the control logic embedded in the human genome is limited by a lack of accurate information of the promoter sequences for most genes. Promoters are a unique class of control sequences, serving as the binding sites for both sequence-specific factors and the general transcription machinery during transcription initiation.
Read the full summary ↓
In order to obtain a comprehensive map of promoters in the human genome, we have determined the location of the RNA polymerase II preinitiation complex throughout the non-repeat sequences of the human genome in primary fibroblast cells. The resulting map defines 10,571 active promoters corresponding to 6,763 known genes and at least 1,199 un-annotated transcriptional units. The map indicates extensive usage of multiple promoters by the human genes and widespread clustering of active promoters in the genome. Further examination of the genome-wide expression profile reveals four general classes of promoters that define the transcriptome of the cell. Our results provide a global view of the functional relationship among the transcriptional machinery, chromatin structure, and gene expression in human cells. Keywords = GALA Keywords = gene expression Keywords = nimblegen Keywords = promoter profile Keywords = LICR renlab Keywords: other
This dataset
Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗
3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE2672_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA92111. Searching any of these in the dataset finder brings you back here.

Samples in this study

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+ 49 more — browse all 49 samples with per-sample file links →

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