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IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors [RNA-Seq]

GSE267261 Mus musculus; Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/10/26 Platform GPL24676Platform GPL24247
Summary
Knocking down IRF2BP2 led to decreased T-cell acute lymphoblastic leukemia (T-ALL) cell survival and growth both in vitro and in vivo. To explore IRF2BP2-dependent gene regulation, RNA-seq analysis was conducted and the differently expressed genes were revealed in the IRF2BP2-knockdown J.gamma1 cells in comparison to control group.
Published in
Super-Enhancer-Driven IRF2BP2 is Activated by Master Transcription Factors and Sustains T-ALL Cell Growth and Survival
Yu J, Zhang Z, Chen Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 39454110 · doi:10.1002/advs.202407113
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Also filed as BioProject PRJNA1110768 and SRA study SRP507194. Searching any of these in the dataset finder brings you back here.

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