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Impact of parental obesity on adipose progenitor programming

GSE267285 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/22 Platform GPL24247
Summary
Parental obesity (PO) increases the risk of obesity and metabolic syndromes in offspring. To investigate how PO influences adipose progenitors, we generated offspring from lean (Ln-F1) or obese (Ob-F1) parents and isolated the stromal vascular fraction (SVF) from inguinal white adipose tissue (iWAT) depots at postnatal day 21 (P21). Bulk RNA sequencing of the SVF was performed to uncover the molecular mechanisms by which PO programs adipose progenitors.
Published in
Early-life ketone body signalling promotes beige fat biogenesis through changes in histone acetylome and β-hydroxybutyrylome
Jiang CL, Lai PH, Yang PC et al. · Nature metabolism 2025 · PMID 41068421 · doi:10.1038/s42255-025-01378-8
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Also filed as BioProject PRJNA1110991 and SRA study SRP507290. Searching any of these in the dataset finder brings you back here.

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