GEO series
Transcriptome analysis of JMML patients compare to healthy prenatal and postnatal samples.
GSE267628
Homo sapiens
Expression profiling by high throughput sequencing
75 samples
2024/05/16
GPL20301
Summary
JMML (Juvenile myelomonocytic leukaemia) is a leukaemia that only develops in young children and is thought to have a prenatal initiation. To study the relationship between JMML and normal ontogeny we studied the transcriptome of HPC (hematopoietic progenitor cells) sorted from sporadic JMML patients, healthy prenatal samples and from healthy age matched donors. Bulk transcriptome of sorted HPC reveals that some JMML samples cluster with prenatal samples whereas other from a distinct cluster apart from any healthy samples.
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