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ACSS2 alleviates alcoholic liver disease via modulating hepcidin-mediated systemic iron homeostasis and hepatic ferroptosis

GSE267638 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/28 Platform GPL24247
Summary
Alcoholic liver disease (ALD) is one of the most prevalent types of liver disease associated with high morbidity and mortality, caused by hepatotoxicity originating from alcohol metabolism, but current therapeutic drugs are still limited. The role of ACSS2 as an enzyme that metabolizes acetate in ALD remains unknown. Our study aimed to investigate the function of ACSS2 and its potential mechanism in ALD progression.
Published in
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression
Wang M, Wen X, Feng Z et al. · Nature communications 2025 · PMID 40593779 · doi:10.1038/s41467-025-61067-8
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Also filed as BioProject PRJNA1112313 and SRA study SRP508101. Searching any of these in the dataset finder brings you back here.

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