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Overexpression of MG53 in mouse intestinal organoids

GSE267687 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/05/21 Platform GPL13112
Summary
Emerging evidence suggests that priming intestinal stem cell (ISC) lineages towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD). However, the mechanism driving such biased lineage commitment remains elusive. Here we show that MG53, also named as TRIM72, plays and important role in maintaining intestinal epithelium integrity against various insults-induced IBD. Specifically, MG53 deficiency leads to exacerbated IBD manifestations caused by various injuries in mice, whereas MG53 overexpression in ISCs is sufficient to ameliorate intestinal damage.
Published in
Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation
Pei Y, Fang M, Wu HK et al. · Signal transduction and targeted therapy 2025 · PMID 40494851 · doi:10.1038/s41392-025-02268-x
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Also filed as BioProject PRJNA1112405 and SRA study SRP508185. Searching any of these in the dataset finder brings you back here.

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