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Single cell sequencing of stromal vascular fraction from facial infiltrating lipomatosis and normal facial adipose tissue

GSE267777 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2024/07/06 Platform GPL24676
Summary
Facial infiltrating lipomatosis is characterized by excessive growth of adipose tissue, The etiology is associated with somatic PIK3CA variant, but the specific mechanisms are not yet fully understood. In this study, we collected facial adipose tissue from both FIL patients and non-FIL individuals, isolated the stromal vascular fraction (SVF) and performed single-cell transcriptome sequencing on these samples. We mapped out the cellular landscape within the SVF and specifically focused on a deeper analysis of fibro-adipogenic precursor cells (FAPs).
Published in
Single-cell sequencing of facial adipose tissue unveils FKBP5 as a therapeutic target for facial infiltrating lipomatosis
Chen H, Sun B, Chang SJ et al. · Stem cell research & therapy 2024 · PMID 39020442 · doi:10.1186/s13287-024-03835-9
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Also filed as BioProject PRJNA1112852 and SRA study SRP508429. Searching any of these in the dataset finder brings you back here.

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