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The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs

GSE268046 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/11 Platform GPL28457
Summary
Bone aging contributes to osteoporosis and impaired bone formation, mechanisms intricately linked to alterations in mesenchymal stem cells (MSCs) that include a metabolic decline whose precise mechanisms remain elusive. In this study, P2rx7 was identified as a key regulator of mitochondrial fitness in bone marrow MSCs during the bone aging process. To validate the role of P2rx7 in bone metabolism and aging, we deleted P2rx7 by using P2rx7 knockout mice and the mice demonstrated premature and exacerbated bone aging. What we want to explore is how P2rx7 knockout affects the genome changes of bone cells.
Published in
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs
Zhuang Z, Han C, Cai M et al. · Journal of advanced research 2026 · PMID 40518112 · doi:10.1016/j.jare.2025.06.026
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Also filed as BioProject PRJNA1114093 and SRA study SRP509052. Searching any of these in the dataset finder brings you back here.

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