HPV16-expressing tumors release multiple IL-1 ligands to orchestrate systemic immunosuppression whose disruption enables efficacy of a therapeutic vaccine.
RNA-seq (gene expression) · mouse · 63 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 63 samples: 57 distinct titles, 3 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- HPV16-Expressing Tumors Release Multiple IL1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic VaccineCancer discovery · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268241_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1115708 and SRA study SRP457640. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 63 sample titles: 57 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7747193 HPV-mice, Replicate 1, Cervix
- GSM7747194 HPV-mice, Replicate 2, Cervix
- GSM7747195 HPV-mice, Replicate 3, Cervix
- GSM7747196 H2B-mice, Replicate 1, Cervix
- GSM7747197 H2B-mice, Replicate 2, Cervix
- GSM7747198 H2B-mice, Replicate 3, Cervix
- GSM7747199 HPV-mice, Replicate 1, Spleen
- GSM7747200 HPV-mice, Replicate 2, Spleen
- GSM7747201 HPV-mice, Replicate 3, Spleen
- GSM7747202 H2B-mice, Replicate 1, Spleen
- GSM7747203 H2B-mice, Replicate 2, Spleen
- GSM7747204 H2B-mice, Replicate 3, Spleen
- GSM7747205 HPV-mice, Replicate 1, Bone Marrow
- GSM7747206 HPV-mice, Replicate 2, Bone Marrow
- GSM7747207 HPV-mice, Replicate 3, Bone Marrow
- GSM7747208 H2B-mice, Replicate 1, Bone Marrow
- GSM7747209 H2B-mice, Replicate 2, Bone Marrow
- GSM7747210 H2B-mice, Replicate 3, Bone Marrow
- GSM7747211 HPV-mice, Replicate 1, Ear
- GSM7747212 HPV-mice, Replicate 2, Ear
- GSM7747213 HPV-mice, Replicate 3, Ear
- GSM7747214 H2B-mice, Replicate 1, Ear
- GSM7747215 H2B-mice, Replicate 2, Ear
- GSM7747216 H2B-mice, Replicate 3, Ear
- GSM7747217 HPV-mice, Replicate 1, Blood
- GSM7747218 HPV-mice, Replicate 2, Blood
- GSM7747219 HPV-mice, Replicate 3, Blood
- GSM7747220 H2B-mice, Replicate 1, Blood
- GSM7747221 H2B-mice, Replicate 2, Blood
- GSM7747222 H2B-mice, Replicate 3, Blood
- GSM8288511 LT2_IS1_1
- GSM8288512 LT2_IS1_2
- GSM8288513 LT2_IS1_3
- GSM8288514 Imp_OE_1
- GSM8288515 Imp_OE_2
- GSM8288516 Imp_OE_3
- GSM8288517 Imp_ctrl_1
- GSM8288518 Imp_ctrl_2
- GSM8288519 Imp_ctrl_3
- GSM8288520 BM1_IL1rap_1
+ 23 more — browse all 63 samples with per-sample file links →
- GSE282799 IL-1 protects from fatal systemic candidiasis by inhibition of oxidative phosphorylation and hypoxia 10 samples shares il-1, systemic
- GSE244660 Oligodendroglial precursors orchestrate immune cellular network instigating multiple sclerosis 10 samples shares orchestrate, multiple
- GSE316584 MicroRNA-224 Orchestrates the BMP Pathway and Represents a New Therapeutic Target for Pulmonary Arterial Hypertension 9 samples shares orchestrate, therapeutic
- GSE341921 PGK1 moonlights as an NF-kB/p65 kinase to orchestrate M2-like macrophage-mediated immunosuppression in triple-negative breast cancer 6 samples shares immunosuppression, orchestrate
- GSE326452 Bulk RNA-seq of mouse brain following closed head injury: role of IL-1R1 signaling 200 samples shares il-1
- GSE75111 Single-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h-IL-17A/GFP+] 151 samples shares il-1
- GSE322757 IL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis 42 samples shares il-1
- GSE282257 Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages 40 samples shares il-1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.