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Single-cell RNA sequencing of antigen specific CD4+ T cells induced by high vs low doses of MHC-II restricted neoantigens

GSE268301 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/05/28 Platform GPL24247
Summary
Here, we report the impact of the dose of the MHC-II restricted neoantigens on the phenotypic and the effector function of tumor-specific CD4 T cells. Whereas vaccines containing low doses of MHC-II-restricted neoantigen (LDVax) generated helper CD4 T cells that promote the proliferation and the cytotoxic functions of CD8 T cells, vaccines containing high doses of MHC-II restricted neoantigen (HDVax) elicited type 1 regulatory T cells that suppress the antitumor immunity.
Published in
Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy
Sultan H, Takeuchi Y, Ward JP et al. · Nature 2024 · PMID 39048822 · doi:10.1038/s41586-024-07752-y
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Also filed as BioProject PRJNA1116136 and SRA study SRP509782. Searching any of these in the dataset finder brings you back here.

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