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Gene expression profile at single cell level from hippocampus of wild type mice and Camk2a-Vps13D KO mice

GSE268343 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/16 Platform GPL34290
Summary
The failure to clear mitochondria, cell death and inflammation have been linked in neurodegenerative disease, but the relationship and role of inflammation in these conditions is not fully understood.To investigate it, we established a model for neurodegeneration caused by mitochondrial impairment by removing Vps13D from the hippocampus.We use single cell RNA sequencing to analyze the gene expression profile of wild type mice and Camk2a-Vps13D KO mice.
Published in
Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration
Miao G, Fortier TM, Liu H et al. · Nature structural & molecular biology 2025 · PMID 40563011 · doi:10.1038/s41594-025-01602-9
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Also filed as BioProject PRJNA1116244 and SRA study SRP509829. Searching any of these in the dataset finder brings you back here.

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