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Effect of 4-octyl itaconate on gene expression of dendritic cells

GSE268402 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/30 Platform GPL24247
Summary
Here, we report that macrophage-derived itaconate exerts a significant suppressive effect on dendritic cell (DC) function. To delve deeper into the impact of itaconate on DCs, we treated bone marrow-derived dendritic cells with 4-OI, a derivative of itaconate, and conducted RNA-seq analysis. Gene-set enrichment analysis (GSEA) of 4-OI-treated DCs showed a general downregulation of innate immunity and immune-response pathways.
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Also filed as BioProject PRJNA1117028 and SRA study SRP510118. Searching any of these in the dataset finder brings you back here.

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