GEO series
ATAC-seq of Keratinocytes and Langerhans cells in normal and hyperproliferative epithelium
GSE268544
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
16 samples
2024/10/30
GPL24247
Summary
In an HPV-induced hyperplastic epithelium mouse model, hyperproliferative Keratinocytes (KCs) showed reduced Interleukin 34 (IL34) expression and chromatin accessibility, associating disturbing cell-cell interaction and immune response genes. Correspondingly, Langerhans cells (LCs) exhibited altered chromatin accessibility, including increased accessibility of IL34's receptor - the colony-stimulating factor 1 receptor (Csf1r) and reduced accessibility in antigen uptake and presentation genes.
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Paper (PMID 39619016) ↗
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