← BioTransfer GEO Dataset Finder
GEO series

BMPR1A-mediated BMP signalling ensures correct mitosis-to-meiosis transition in mouse fetal ovarian germ cells, in vivo

GSE268565 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/01/16 Platform GPL24247
Summary
A successful mitosis-to-meiosis transition in germ cells is essential for fertility in sexually reproducing organisms. In mice and humans, it is established that STRA8 expression is critical for meiotic onset in both sexes. Here we show that BMP signalling is also essential, not for STRA8 induction but for correct meiotic progression in mouse fetal ovarian germ cells. Germ cell-specific deletion of Bmpr1a caused aberrant expression of meiotic, pluripotency, and cell cycle genes in E14.5 mouse fetal ovaries. Our results verify a role for BMP signalling in instructing germ cell meiosis in female mice in vivo, and shed light on the regulatory mechanisms underlying fetal germ cell development.
Published in
BMP and STRA8 act collaboratively to ensure correct mitotic-to-meiotic transition in the fetal mouse ovary
Cheung FKM, Feng CA, Crisp C et al. · Development (Cambridge, England) 2025 · PMID 39817676 · doi:10.1242/dev.204227
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE268565_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1117811 and SRA study SRP510514. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.