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The nBAF complex subunit CREST/SS18L1 regulates hippocampal memory processes via tyrosine 397 and histone acetyltransferase CBP

GSE268687 Mus musculus (mouse) RNA-seq (gene expression) 30 samples Submitted 2026/02/24 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 30 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
30 samples: 5 conditions, mostly with about 6 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
The nBAF complex subunit CREST/SS18L1 regulates hippocampal memory processes via tyrosine 397 and histone acetyltransferase CBPCell reports · 2026
Summary (written by the submitters)
Chromatin modifying/remodeling machinery are important for learning-induced transcriptional activity, yet it remains unclear how they coordinate to drive de novo gene expression for memory formation. Here, we examine the transcription factor known as calcium-responsive transactivator (CREST) in memory formation, synaptic plasticity and learning-induced gene expression.
Read the full summary ↓
CREST is known to bind major chromatin modifying and remodeling machinery via interaction with CREB-binding protein (CBP) and brahma-related gene 1 (BRG1), respectively. In silico modeling of CREST identified tyrosine 397 (Y397) within the CBP binding domain. Expression of a CREST Y397F point-mutant impairs long-term potentiation and memory. Conversely, expression of a CREST Y397D point-mutant enhances memory in a CBP-dependent manner. Differential gene expression analysis reveals distinct CREST Y397-regulated signatures during memory consolidation. CBP acts through CREB and post-translation modifications to affect memory, but the findings of this study argue for the consideration of the CREST-CBP interaction and Y397 accessibility as factors for memory processes.
Published in
The nBAF complex subunit CREST/SS18L1 regulates hippocampal memory processes via tyrosine 397 and histone acetyltransferase CBP
Garcia FG, Farias de Albuquerque M, Johnson V et al. · Cell reports 2026 · PMID 41886450 · doi:10.1016/j.celrep.2026.117158
This dataset
Open GSE268687 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268687_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1118268 and SRA study SRP510847. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41886450) ↗
Study design
5 conditions, mostly with about 6 replicates each
dorsal hippocampus, homecage, vehicle, ×6 dorsal hippocampus, 1hr after 10min threshold… ×6 dorsal hippocampus, 1hr after 10min threshold… ×6 dorsal hippocampus, 1hr after 3min sub-thresh… ×6 dorsal hippocampus, 1hr after 3min sub-thresh… ×6

Supports a between-group comparison across 30 samples.

How we read this: 5 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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