MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 16 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid LeukemiaCancer discovery · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283530_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1194476 and SRA study SRP549529. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8665956 mm202C_ChIP_Brpf1_Combo_72h_REP1_240904_TGACCA_S4
- GSM8665957 mm202C_ChIP_Brpf1_DMSO_72h_REP1_240904_ATCACG_S1
- GSM8665958 mm202C_ChIP_Brpf1_PF9363_500nM_72h_REP1_240904_TTAGGC_S3
- GSM8665959 mm202C_ChIP_Brpf1_SNDX_2uM_72h_REP1_240904_CGATGT_S2
- GSM8665960 mm202C_ChIP_HA_Combo_72h_REP1_240904_ACTTGA_S8
- GSM8665961 mm202C_ChIP_HA_DMSO_72h_REP1_240904_ACAGTG_S5
- GSM8665962 mm202C_ChIP_HA_PF9363_500nM_72h_REP1_240904_CAGATC_S7
- GSM8665963 mm202C_ChIP_HA_SNDX_2uM_72h_REP1_240904_GCCAAT_S6
- GSM8665964 mm202C_ChIP_input_Combo_72h_REP1_240904_GTTTCG_S20
- GSM8665965 mm202C_ChIP_input_DMSO_72h_REP1_240904_GTCCGC_S17
- GSM8665966 mm202C_ChIP_input_PF9363_500nM_72h_REP1_240904_GTGGCC_S19
- GSM8665967 mm202C_ChIP_input_SNDX_2uM_72h_REP1_240904_GTGAAA_S18
- GSM8665968 mm202C_ChIP_MLL1_Combo_72h_REP1_240904_CCGTCC_S16
- GSM8665969 mm202C_ChIP_MLL1_DMSO_72h_REP1_240904_AGTCAA_S13
- GSM8665970 mm202C_ChIP_MLL1_PF9363_500nM_72h_REP1_240904_ATGTCA_S15
- GSM8665971 mm202C_ChIP_MLL1_SNDX_2uM_72h_REP1_240904_AGTTCC_S14
- GSE303625 MYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia [RNA-Seq] 14 samples shares acetyltransferase, therapeutic, leukemia
- GSE281967 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [bullk ATAC-seq] 21 samples shares hbo1, complexes
- GSE303263 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [802T4] 12 samples shares hbo1, complexes
- GSE303178 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [KPTC CUT&RUN] 12 samples shares hbo1, complexes
- GSE303264 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [KP787] 11 samples shares hbo1, complexes
- GSE282851 Functional mapping of epigenomic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes [scRNA-seq] 10 samples shares hbo1, complexes
- GSE274891 Effect of temozolomide resistant on gene expression in mouse neuroblastoma tumor [ChIPseq] 24 samples shares moz
- GSE287243 KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan [CUT&TAG] 20 samples shares moz
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.