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Predisposition to hematopoietic malignancies by deleterious germline CHEK2 variants

GSE268966 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/05/01 Platform GPL24247
Summary
The role of germline CHEK2 variants in hematopoietic malignancies (HMs) is poorly understood. We examined pathogenic/likely pathogenic (P/LP) CHEK2 variants in a hereditary hematopoietic malignancy (HHM) and solid tumor risk cohorts, the UK Biobank, public acute myeloid leukemia (AML) datasets, and a knock-in mouse model. This submission is for the data from Chek2 p.161T mice,sorted CD34+ Bone Marrow cells,Bulk RNA Sequencing.
Published in
Predisposition to hematopoietic malignancies by deleterious germline CHEK2 variants
Stubbins RJ, Arnovitz S, Vagher J et al. · Leukemia 2025 · PMID 40335619 · doi:10.1038/s41375-025-02635-1
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Also filed as BioProject PRJNA1119518 and SRA study SRP511480. Searching any of these in the dataset finder brings you back here.

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