Engineering effector domains of MEF2C and GATA4 enhances cardiac reprogramming
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 × MEF, Ctrl vs 5 × iCM, MGT vs 5 × iCM, MΔGΔTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Shortening and optimization of MEF2C and GATA4 promote cardiac reprogrammingBiochemical and biophysical research communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300140_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1279100 and SRA study SRP592916. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 3 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9054326 MEF, Ctrl1 MEF, Ctrl
- GSM9054327 MEF, Ctrl2 MEF, Ctrl
- GSM9054328 MEF, Ctrl3 MEF, Ctrl
- GSM9054329 MEF, Ctrl4 MEF, Ctrl
- GSM9054330 MEF, Ctrl5 MEF, Ctrl
- GSM9054331 iCM, MGT1 iCM, MGT
- GSM9054332 iCM, MGT2 iCM, MGT
- GSM9054333 iCM, MGT3 iCM, MGT
- GSM9054334 iCM, MGT4 iCM, MGT
- GSM9054335 iCM, MGT5 iCM, MGT
- GSM9054336 iCM, MΔGΔT1 iCM, MΔGΔT
- GSM9054337 iCM, MΔGΔT2 iCM, MΔGΔT
- GSM9054338 iCM, MΔGΔT3 iCM, MΔGΔT
- GSM9054339 iCM, MΔGΔT4 iCM, MΔGΔT
- GSM9054340 iCM, MΔGΔT5 iCM, MΔGΔT
- GSE218761 Cardiac reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction 18 samples shares gata4, reprogramming, cardiac
- GSE263625 Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases 19 samples shares reprogramming, enhances
- GSE305170 Maintenance of Fibroblast Identity During Cardiac Reprogramming and Heart Repair [RNA-seq] 18 samples shares reprogramming, cardiac
- GSE261139 Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential 16 samples shares reprogramming, enhances
- GSE305453 Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo 15 samples shares reprogramming, cardiac
- GSE324502 Bioinspired, Mitochondria-targeted Single-atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism 12 samples shares reprogramming, enhances
- GSE267466 Blocking Nuclear Receptor Nr4a3 Unlocks the Senescence Barrier to Promote Direct Cardiac Reprogramming 12 samples shares reprogramming, cardiac
- GSE236247 The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC Reprogramming 68 samples shares reprogramming, enhances
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.