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Effect of maternal obesogenic diet exposure on murine Neurofibromatosis Type 1 optic pathway glioma

GSE269517 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/27 Platform GPL34290
Summary
Pediatric low-grade glioma incidence has been rising in the U.S., mirroring the rising rates of pediatric and maternal obesity. Recently, children of obese mothers were demonstrated to develop brain tumors at higher rates. Importantly, obesity in the U.S. is largely driven by diet, given the abudnance of high fat and high sugar food choices. We identified that combined maternal and postnatal obesogenic (Ob) diet exposure accelerated glioma formation in murine Neurofibromatosis type 1 (Nf1) optic pathway glioma (OPG)-forming mice, a model of pediatric glioma formation. Postnatal dietary exposure alone could not fully recaptiulate these effects, indicating maternal exposure was critical for this phenotype. To determine how Ob exposure affected gene expression in the optic nerve, we isolated Ob-exposed versus CD-exposed optic nerves and performed RNASeq. Enriched pathways included nervous system development, neuronal signaling and appetite regulation.
Published in
Maternal obesogenic diet operates at the tumor cell of origin to increase incidence and decrease latency of neurofibromatosis type 1 optic pathway glioma
Chan A, Zhang K, Martin G et al. · Neuro-oncology 2024 · PMID 39023130 · doi:10.1093/neuonc/noae136
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Also filed as BioProject PRJNA1122182 and SRA study SRP513021. Searching any of these in the dataset finder brings you back here.

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