The role of EZH2 in sepsis-induced acute lung injury [RNA-Seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × sham vs 3 × CLP vs 3 × EZH2KO sham vs 3 × EZH2KO CLPGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EZH2 contributes to sepsis-induced acute lung injury through regulating macrophage polarizationBiochimica et biophysica acta. Molecular basis of disease · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269740_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1123592 and SRA study SRP513688. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8325947 sham1 sham
- GSM8325948 sham2 sham
- GSM8325949 sham3 sham
- GSM8325950 CLP1 CLP
- GSM8325951 CLP2 CLP
- GSM8325952 CLP3 CLP
- GSM8325953 EZH2KO sham1 EZH2KO sham
- GSM8325954 EZH2KO sham2 EZH2KO sham
- GSM8325955 EZH2KO sham3 EZH2KO sham
- GSM8325956 EZH2KO CLP1 EZH2KO CLP
- GSM8325957 EZH2KO CLP2 EZH2KO CLP
- GSM8325958 EZH2KO CLP3 EZH2KO CLP
- GSE278767 Decoding the Multiple Functions of ZBP1 in the Mechanism of Sepsis-Induced Acute Lung Injury 14 samples shares sepsis-induced, injury, acute, lung
- GSE264278 TIme-cource single-cell RNA-seq analysis of bleomycin and LPS-induced lung injury and fibrosis 18 samples shares rna-seq, injury, lung
- GSE237260 Transcriptome Analysis Reveals Gene Expression Changes in a mouse Model of Hyperoxia-induced acute lung injury 12 samples shares injury, acute, lung
- GSE276682 Single-cell transcriptome analysis revealed cellular reprogramming following Tetramethylpyrazine treatment in LPS-induced acute lung injury 12 samples shares injury, acute, lung
- GSE326452 Bulk RNA-seq of mouse brain following closed head injury: role of IL-1R1 signaling 200 samples shares rna-seq, injury
- GSE280003 Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung 81 samples shares injury, lung
- GSE300288 Single-cell and spatial transcriptomics analysis of tobacco-associated lung adenocarcinoma development, and in response to targeting inflammation alone or in combination with immune checkpoint blockade in precancerous phase [scRNA-seq] 31 samples shares rna-seq, lung
- GSE173999 Single-cel RNA-seq of Mouse Olfactory Epithelium for Understanding Age-associated Neuronal Injury Response 19 samples shares rna-seq, injury
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.