The antiviral nuclear body protein SP140 represses Ifnb1 transcript stabilization by the novel regulator RESIST [RNA-seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × RNA-seq, IFNAR KO, DMXAA treated, vs 3 × RNA-seq, SP140 IFNAR KO, DMXAA treated, vs 3 × RNA-seq, IFNAR KO, untreated, vs 3 × RNA-seq, SP140 IFNAR KO, untreated,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunitybioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269761_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1123644 and SRA study SRP513736. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8326508 RNA-seq, IFNAR KO, DMXAA treated, rep 1 RNA-seq, IFNAR KO, DMXA…
- GSM8326509 RNA-seq, IFNAR KO, DMXAA treated, rep 2 RNA-seq, IFNAR KO, DMXA…
- GSM8326510 RNA-seq, IFNAR KO, DMXAA treated, rep 3 RNA-seq, IFNAR KO, DMXA…
- GSM8326511 RNA-seq, SP140 IFNAR KO, DMXAA treated, rep 1 RNA-seq, SP140 IFNAR KO…
- GSM8326512 RNA-seq, SP140 IFNAR KO, DMXAA treated, rep 2 RNA-seq, SP140 IFNAR KO…
- GSM8326513 RNA-seq, SP140 IFNAR KO, DMXAA treated, rep 3 RNA-seq, SP140 IFNAR KO…
- GSM8326514 RNA-seq, IFNAR KO, untreated, rep 1 RNA-seq, IFNAR KO, untr…
- GSM8326515 RNA-seq, IFNAR KO, untreated, rep 2 RNA-seq, IFNAR KO, untr…
- GSM8326516 RNA-seq, IFNAR KO, untreated, rep 3 RNA-seq, IFNAR KO, untr…
- GSM8326517 RNA-seq, SP140 IFNAR KO, untreated, rep 1 RNA-seq, SP140 IFNAR KO…
- GSM8326518 RNA-seq, SP140 IFNAR KO, untreated, rep 2 RNA-seq, SP140 IFNAR KO…
- GSM8326519 RNA-seq, SP140 IFNAR KO, untreated, rep 3 RNA-seq, SP140 IFNAR KO…
- GSE269808 The antiviral nuclear body protein SP140 represses Ifnb1 transcript stabilization by the novel regulator RESIST [WT and SP140 KO RNA-seq] 12 samples shares resist, sp140, ifnb1, stabilization, transcript, antiviral, represses, regulator
- GSE269811 The antiviral nuclear body protein SP140 represses Ifnb1 transcript stabilization by the novel regulator RESIST [ATAC-seq] 12 samples shares resist, sp140, ifnb1, stabilization, transcript, antiviral, represses, regulator
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares resist, regulator
- GSE281823 Transcriptional profiling of striatum from the Q140 mouse model of Huntington's disease, from A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy 40 samples shares resist, transcript
- GSE268778 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [scRNA-seq] 20 samples shares resist, regulator
- GSE275780 Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy [RNA-seq] 17 samples shares resist, regulator
- GSE302064 Transcriptome analysis of the effect of RAD52 knockout on olaparib response in BRCA2-deficient, olaparib-resistant murine ovarian cancer cells (ID8-OR) 12 samples shares resist, transcript
- GSE184366 Whole transcriptome analysis of white adipose tissue in high fat diet induced insulin resistance mice 16 samples shares resist, transcript
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.