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SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription [scRNA-Seq]

GSE269773 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2025/06/10 Platform GPL34328
Summary
In order to profile the transcriptional changes that accompany SyS development along disparate epithelial, mesenchymal, or poorly differentiated trajectories, we performed single cell transcriptome profiling (scRNA-seq) on mouse SyS tumors similar to those profiled epigenomically. The tumors exhibited a variety of histomorphologies, indicated in hematoxylin and eosin tumor sections of tissue immediately adjacent to that submitted for scRNA-seq.
Published in
Synovial sarcoma reprograms transcription by GBAF activation of polycomb targets and loss of CBAF enhancers
Li J, Li L, Smith-Fry K et al. · Nature communications 2025 · PMID 41423472 · doi:10.1038/s41467-025-67841-y
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Also filed as BioProject PRJNA1123666 and SRA study SRP513742. Searching any of these in the dataset finder brings you back here.

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