RCOR2 downregulates CIITA via HDAC1-mediated histone deacetylation in cancer cells [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Tumoral RCOR2 promotes tumor development through dual epigenetic regulation of tumor plasticity and immunogenicityThe Journal of clinical investigation · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270024_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1124879 and SRA study SRP514313. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8332937 MDA-MB-231-HA-RCOR2, HA, CST, rep1 MDA-MB-231-HA-RCOR2, HA…
- GSM8332938 MDA-MB-231-HA-RCOR2, HA, CST, rep2 MDA-MB-231-HA-RCOR2, HA…
- GSM8332939 MDA-MB-231, Input for HA-RCOR2, rep1 MDA-MB-231, Input for H…
- GSM8332940 MDA-MB-231, Input for HA-RCOR2, rep2 MDA-MB-231, Input for H…
- GSM8332941 MDA-MB-231, parental, HDAC1, Bethyl, rep1 MDA-MB-231, parental, H…
- GSM8332942 MDA-MB-231, parental, HDAC1, Bethyl, rep2 MDA-MB-231, parental, H…
- GSM8332943 MDA-MB-231, RCOR2-KO1, HDAC1, Bethyl, rep1 MDA-MB-231, RCOR2-KO1, …
- GSM8332944 MDA-MB-231, RCOR2-KO1, HDAC1, Bethyl, rep2 MDA-MB-231, RCOR2-KO1, …
- GSM8332945 MDA-MB-231, parental, Input for HDAC1, rep1 MDA-MB-231, parental, I…
- GSM8332946 MDA-MB-231, parental, Input for HDAC1, rep2 MDA-MB-231, parental, I…
- GSM8332947 MDA-MB-231, RCOR2-KO1, Input for HDAC1, rep1 MDA-MB-231, RCOR2-KO1, …
- GSM8332948 MDA-MB-231, RCOR2-KO1, Input for HDAC1, rep2 MDA-MB-231, RCOR2-KO1, …
- GSE269916 RCOR2 downregulates RNF43 via LSD1-mediated histone demethylation in cancer cells 8 samples shares rcor2, downregulates, histone
- GSE281212 Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma [ChIP-seq 1] 16 samples shares rcor2, chip-seq
- GSE281213 Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma [ChIP-Seq 2] 10 samples shares rcor2, chip-seq
- GSE237956 ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [ChIP-seq] 8 samples shares ciita, chip-seq
- GSE305252 Lactyl-HDAC1-Mediated Epigenetic Gating of Angiogenic Transcription via Metabolic Reprogramming [ChIP-seq] 2 samples shares hdac1-mediated, chip-seq
- GSE237957 ZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression [FAIRE-seq] 8 samples shares ciita
- GSE270022 Effect of RCOR2 in cancer cell stemness and immune evasion 6 samples shares rcor2
- GSE281088 Non-canonical activating roles of RCoR2 sustain transcription in adrenergic neuroblastoma [ATAC-seq] 4 samples shares rcor2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.