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Identification of PRMT5 as a therapeutic target in cholangiocarcinoma [RNA-seq II]

GSE270181 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/17 Platform GPL30172
Summary
Cholangiocarcinoma is a very aggressive cancer whose incidence is increasing. Moreover, chemotherapies are little effective and the response to immune checkpoint inhibitors is low. We have identified protein arginine-methyltransferase 5 (PRMT5) as a novel therapeutic target in cholangiocarcinoma. Treatment with PRMT5 inhibitor significantly restrains the growth of experimental cholangiocarcinoma model TAZ/AKT without adverse effects. Our findings support the evaluation of PRMT5 inhibitors in clinical trials.
Published in
Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
Elurbide J, Colyn L, Latasa MU et al. · Gut 2024 · PMID 39266051 · doi:10.1136/gutjnl-2024-332998
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Also filed as BioProject PRJNA1125608 and SRA study SRP514779. Searching any of these in the dataset finder brings you back here.

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