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Hinokiflavone resists HFD-induced obesity by promoting apoptosis in an IGF2BP2-mediated Bim m6A modification dependent manner

GSE270326 Mus musculus Expression profiling by high throughput sequencing; Other 7 samples Submitted 2024/10/16 Platform GPL24247
Summary
Obesity has emerged as a major health risk on a global scale. Natural small molecules, such as hinokiflavone (HF) extracted from plants like cypress, exhibit diverse chemical structures and low synthesis costs. Using HFD-induced obese mice models, we found that HF suppresses obesity by inducing apoptosis in adipose tissue. Adipocyte apoptosis helps maintain tissue health by removing aging, damaged, or excess fat cells, crucial in preventing obesity and metabolic diseases. We found that HF can specifically bind to insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) to promote the stability of N6-methyladenosine (m6A) -modified Bim, inducing mitochondrial outer membrane permeabilization (MOMP). MOMP leads to Caspase9/3-mediated adipocyte mitochondrial pathway apoptosis, alleviating obesity induced by a high-fat diet. HF offers a controlled means of adipocyte apoptosis for weight loss. This study reveals the potential of small molecules like HF in developing new therapeutic approaches in drug development and biomedical research.
Published in
Hinokiflavone resists HFD-induced obesity by promoting apoptosis in an IGF2BP2-mediated Bim m(6)A modification dependent manner
Wang M, Chao M, Han H et al. · The Journal of biological chemistry 2024 · PMID 39214307 · doi:10.1016/j.jbc.2024.107721
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Also filed as BioProject PRJNA1126200 and SRA study SRP515160. Searching any of these in the dataset finder brings you back here.

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