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Targeting CAFs-Mediated Stromal Signaling in a Patient-Derived Organotypic Colorectal Tumor Model

GSE270613 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/02/19 Platform GPL24676
Summary
The goal of this experiment is to understand why co-culturing colon cancer cells with carcinoma associated fibroblasts (CAFs) causes the colon cancer cells to develop chemo-resistance. We cultured a patient-derived colon cancer cell model derived from conditional reprogramming with or without carcinoma-associated fibroblasts. Before sequencing, the co-cultured cells were purified using EpCAM immuno-magnetic beads to isolate cancer cells.
Published in
Targeting CAFs-Mediated Stromal Signaling in a Patient-Derived Organotypic Colorectal Tumor Model
Lamichhane A, Guragain P, Heiss J et al. · Molecular cancer therapeutics 2025 · PMID 40228090 · doi:10.1158/1535-7163.MCT-24-0756
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Also filed as BioProject PRJNA1127568 and SRA study SRP515858. Searching any of these in the dataset finder brings you back here.

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