GEO series
Transcriptional profiling of tumor infiltrating and ciculating T lymphocytes of mice harboring MOC1 tumors
GSE270954
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2024/08/21
GPL24247
Summary
Combination TGF-β neutralization and PD-L1 immune checkpoint blockade promotes anti-tumoral systemic immunity by enhancing tumor egress of CD8+ TILs. This enhanced egress associated with reduced expression of the tissue residency marker Itgae and its upstream regulator Znf683, with the circulating CD8+ T cells expressing higher Cxcr3, an observation made as well in samples from patients treated with dual TGF- neutralization and ICB.
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Paper (PMID 39139402) ↗
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