mTOR Signaling Regulates Multiple Metabolic Pathways in Human Lung Fibroblasts After TGF-β and in Pulmonary Fibrosis
RNA-seq (gene expression) · human · 28 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 28 samples: 8 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- mTOR signaling regulates multiple metabolic pathways in human lung fibroblasts after TGF-β and in pulmonary fibrosisAmerican journal of physiology. Lung cellular and molecular physiology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270973_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1129140 and SRA study SRP516610. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 8 replicated groups read from 28 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8366458 siControl_UT_1 siControl_UT
- GSM8366459 siControl_UT_2 siControl_UT
- GSM8366460 siControl_UT_3 siControl_UT
- GSM8366461 siControl_TGFb_1 siControl_TGFb
- GSM8366462 siControl_TGFb_2 siControl_TGFb
- GSM8366463 siControl_TGFb_3 siControl_TGFb
- GSM8366464 siATF4_UT_1 siATF4_UT
- GSM8366465 siATF4_UT_2 siATF4_UT
- GSM8366466 siATF4_UT_3 siATF4_UT
- GSM8366467 siATF4_TGFb_1 siATF4_TGFb
- GSM8366468 siATF4_TGFb_2 siATF4_TGFb
- GSM8366469 siATF4_TGFb_3 siATF4_TGFb
- GSM8366470 UT_1 UT
- GSM8366471 UT_2 UT
- GSM8366472 UT_3 UT
- GSM8366473 UT_4 UT
- GSM8366474 TGFb_1 TGFb
- GSM8366475 TGFb_2 TGFb
- GSM8366476 TGFb_3 TGFb
- GSM8366477 TGFb_4 TGFb
- GSM8366478 Torin1_1 Torin1
- GSM8366479 Torin1_2 Torin1
- GSM8366480 Torin1_3 Torin1
- GSM8366481 Torin1_4 Torin1
- GSM8366482 TGFb_Torin1_1 TGFb_Torin1
- GSM8366483 TGFb_Torin1_2 TGFb_Torin1
- GSM8366484 TGFb_Torin1_3 TGFb_Torin1
- GSM8366485 TGFb_Torin1_4 TGFb_Torin1
- GSE272972 Critical role for the TGF-β1/mTORC1 signalling axis in defining the transcriptional identity of CTHRC1+ pathologic fibroblasts in idiopathic pulmonary fibrosis 18 samples shares tgf, fibroblasts, pulmonary, fibrosis, mtor
- GSE331144 Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosis 9 samples shares fibroblasts, fibrosis, lung
- GSE92592 mRNA Sequencing of Ideopathic Pulmonary Fibrosis (IPF) and Control Samples from the Lung Tissue Research Consortium (LTRC) 39 samples shares pulmonary, fibrosis, lung
- GSE335339 PUS7-Mediated Pseudouridylation of TGFBI Drives Vascular Remodeling in Pulmonary Hypertension [BID-seq] 20 samples shares tgf, pulmonary
- GSE215274 Identification of Whole Blood Gene Expression Signature to Predict the Therapeutic Effect of Nintedanib in Idiopathic Pulmonary Fibrosis 177 samples shares pulmonary, fibrosis
- GSE310058 Single-nucleus transcriptomic profiling of human lung tissue in chronic obstructive pulmonary disease (COPD) [snRNA-seq] 149 samples shares pulmonary, lung
- GSE254617 Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension. 148 samples shares pulmonary, lung
- GSE273882 Arginine Promotes The Activation of Human Lung Fibroblasts Independent of Its Metabolism 52 samples shares fibroblasts, lung
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.