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Single-cell RNA sequencing reveals the CRTAC1+ population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1+ macrophage

GSE271018 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/07/31 Platform GPL24676
Summary
Degenerative spinal stenosis is a chronic disease that affects the spinal ligaments and associated bones, resulting in back pain and disorders of the limbs among the elderly population. There are few preventive strategies for such ligament degeneration. We here aimed to establish a comprehensive transcriptomic atlas of ligament tissues to identify high-priority targets for pharmaceutical treatment of ligament degeneration. Here, single-cell RNA sequencing was performed on six degenerative ligaments and three traumatic ligaments to understand tissue heterogeneity.
Published in
Single-cell RNA sequencing reveals the CRTAC1(+) population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1(+) macrophage
Tang Y, Zhuo D, Yu Y et al. · Aging cell 2024 · PMID 39158018 · doi:10.1111/acel.14320
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Also filed as BioProject PRJNA1129430 and SRA study SRP516755. Searching any of these in the dataset finder brings you back here.

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