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RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond [RNA-seq]

GSE271019 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/02 Platform GPL24247
Summary
RNA modifications, including adenosine-to-inosine (A-to-I) editing, are fundamental for normal brain physiology, as they participate in multiple biological processes and pathological conditions. These modifications can alter RNA secondary structures and affinity for RNA-binding proteins, thereby influencing RNA processing mechanisms such as alternative splicing. In this study, we investigated A-to-I RNA editing and its impact on alternative splicing regulation in the mouse brain using ADAR enzyme-deficient mice. We analyzed the brain transcriptome of ADAR2 knockout (Adar2−/−Gria2R/R), as well as double ADAR1 catalytically inactive / ADAR2 knockout (Adar1E861A/E861A Ifih−/− Adar2−/−Gria2R/R) mice compared to wild-type controls, identifying alternative splicing events associated with the absence of ADAR1 and ADAR2 specific A-to-I editing.
Published in
RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond
Larrea E, Tellaetxe-Abete M, Peng Y et al. · Scientific reports 2025 · PMID 41310151 · doi:10.1038/s41598-025-30030-4
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Also filed as BioProject PRJNA1129431 and SRA study SRP516751. Searching any of these in the dataset finder brings you back here.

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