GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × RAW264.7, control vs 3 × RAW264.7, LPS vs 3 × RAW264.7, SP+LPS vs 3 × RAW264.7, SB+LPSGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axisNature communications · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271034_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1129455 and SRA study SRP516810. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8367584 RAW264.7, control1 RAW264.7, control
- GSM8367585 RAW264.7, control2 RAW264.7, control
- GSM8367586 RAW264.7, control3 RAW264.7, control
- GSM8367587 RAW264.7, LPS1 RAW264.7, LPS
- GSM8367588 RAW264.7, LPS2 RAW264.7, LPS
- GSM8367589 RAW264.7, LPS3 RAW264.7, LPS
- GSM8367590 RAW264.7, SP+LPS1 RAW264.7, SP+LPS
- GSM8367591 RAW264.7, SP+LPS2 RAW264.7, SP+LPS
- GSM8367592 RAW264.7, SP+LPS3 RAW264.7, SP+LPS
- GSM8367593 RAW264.7, SB+LPS1 RAW264.7, SB+LPS
- GSM8367594 RAW264.7, SB+LPS2 RAW264.7, SB+LPS
- GSM8367595 RAW264.7, SB+LPS3 RAW264.7, SB+LPS
- GSE262105 Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5/NR4a1 axis 21 samples shares remodeling, axis
- GSE285771 Orai1 in pancreatic ductal cells mediates pancreas-intestinal crosstalk in experimental acute pancreatitis via the secretion of antimicrobial peptide REG3B in pancreatic juice 18 samples shares pancreatitis, acute
- GSE248386 ILC2 regulate a Pi16+ fibroblast progenitor niche in the pancreas (acute pancreatitis scRNA-seq) 10 samples shares pancreatitis, acute
- GSE274492 The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis [Valid RNA-Seq] 200 samples shares remodeling
- GSE259380 TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody induces tumor regression through profound tumor microenvironment remodeling and strong antitumor adaptive immune response [RNA-seq] 149 samples shares remodeling
- GSE300757 Efferocytosis induces proangiogenic function and chromatin remodeling in tumor-associated macrophages 127 samples shares remodeling
- GSE276784 Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche 89 samples shares remodeling
- GSE239602 Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during murine atherosclerosis 82 samples shares remodeling
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.