Nuclear translocation of TfR1 facilitating tumor progression via p53-mediated gene regulation [RNA-seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × HCT-116-shscr-RNA-seq vs 3 × HCT-116-shTfR1-RNA-seq vs 3 × HCT-116-shscr-CDDP-RNA-seq vs 3 × HCT-116-shTfR1-CDDP-RNA-seqGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271109_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1129875 and SRA study SRP517026. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8369918 HCT-116-shscr-RNA-seq 1 HCT-116-shscr-RNA-seq
- GSM8369919 HCT-116-shscr-RNA-seq 2 HCT-116-shscr-RNA-seq
- GSM8369920 HCT-116-shscr-RNA-seq 3 HCT-116-shscr-RNA-seq
- GSM8369921 HCT-116-shTfR1-RNA-seq 1 HCT-116-shTfR1-RNA-seq
- GSM8369922 HCT-116-shTfR1-RNA-seq 2 HCT-116-shTfR1-RNA-seq
- GSM8369923 HCT-116-shTfR1-RNA-seq 3 HCT-116-shTfR1-RNA-seq
- GSM8369924 HCT-116-shscr-CDDP-RNA-seq 1 HCT-116-shscr-CDDP-RNA-…
- GSM8369925 HCT-116-shscr-CDDP-RNA-seq 2 HCT-116-shscr-CDDP-RNA-…
- GSM8369926 HCT-116-shscr-CDDP-RNA-seq 3 HCT-116-shscr-CDDP-RNA-…
- GSM8369927 HCT-116-shTfR1-CDDP-RNA-seq 1 HCT-116-shTfR1-CDDP-RNA…
- GSM8369928 HCT-116-shTfR1-CDDP-RNA-seq 2 HCT-116-shTfR1-CDDP-RNA…
- GSM8369929 HCT-116-shTfR1-CDDP-RNA-seq 3 HCT-116-shTfR1-CDDP-RNA…
- GSE271155 Nuclear translocation of TfR1 facilitating tumor progression via p53-mediated gene regulation 42 samples shares tfr1, translocation, facilitating, p53-mediated, progression, nuclear
- GSE271110 Nuclear translocation of TfR1 facilitating tumor progression via p53-mediated gene regulation [Cut&Tag] 30 samples shares tfr1, translocation, facilitating, p53-mediated, progression, nuclear
- GSE296538 DNA Damage-Induced Nuclear STING Translocation Orchestrates Innate Immune Activation and Chromatin Remodeling [RNA-Seq] 8 samples shares translocation, nuclear, rna-seq
- GSE264360 Nuclear translocation of Cx43 promotes CRC progression by CAF via activating β-catenin through TGF-β and phosphorylation 6 samples shares translocation, progression, nuclear
- GSE268092 TFE3 fusion proteins drive oxidative metabolism, ferroptosis resistance and general RNA synthesis in translocation renal cell carcinoma. [RNA-seq] 36 samples shares translocation, rna-seq
- GSE266517 Metabolic reprogramming driven by TFE3 fusions unveils novel vulnerabilities in translocation renal cell carcinoma [RNA-Seq] 24 samples shares translocation, rna-seq
- GSE253892 PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma [RNA-seq] 18 samples shares translocation, rna-seq
- GSE293936 HMGB3 promotes brain metastasis in lung adenocarcinoma by recruiting SSBP1 for nuclear translocation to remodel mitochondrial metabolism 12 samples shares translocation, nuclear
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.