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Long-term transcriptome-wide therapeutic effects of AAV-hpCas13d

GSE271526 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/05 Platform GPL24247
Summary
To fully understand the enduring therapeutic effects of hpCas13d and its potential for clinical translation, comprehensive investigation is needed. In this study, we employed RNA-sequencing to analyze transcriptome alterations in Myh6RH/+ hearts, Myh6RH/RQ hearts, and hpCas13d[RQ]-treated Myh6RH/RQ hearts, aiming to elucidate the molecular mechanisms underlying the regression of cardiac hypertrophy induced by hpCas13d[RQ] treatment.
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Direct links to NCBI, no account and no request form: the whole study as GSE271526_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1132169 and SRA study SRP518118. Searching any of these in the dataset finder brings you back here.

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