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Effect of metformin in the mouse ileum gene expression

GSE271623 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/22 Platform GPL24247
Summary
Metformin is first line treatment for type 2 diabetes, however its exact mechanisms remain incompletely understood. Furthermore, the role of glucose transporter in intestine are highlighted to investigate metabolic change. We here report RNA change after metformin treatment in ileum tissue. We are going to focus on change of glucose transporter and relate factor of those changes. In previous study metformin increases expression of GLUT1/GLUT2 in ileum and metformin plays role as complex1 inhibitor so we are going to find target of metformin-induced glucose metabolic increasment
Published in
Novel mechanism whereby metformin improves glucose homeostasis: TXNIP-GLUT1 axis modulation enhances intestinal glucotonic effects
Kang CW, Nam JH, Oh JH et al. · Experimental & molecular medicine 2025 · PMID 40770064 · doi:10.1038/s12276-025-01518-w
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Also filed as BioProject PRJNA1132520 and SRA study SRP518289. Searching any of these in the dataset finder brings you back here.

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