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Elane mediates neutrophil infiltration into the brain and neuroinflammation

GSE271724 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/17 Platform GPL24247
Summary
In CUMS mice, neutrophils can infiltrate brain parenchyma and induce neuroinflammatory responses. To identify potential mediators, we analyzed the gene expression profiles of bone marrow neutrophils from mice subjected to CUMS and compared them with those of control mice. Interestingly, among the genes notably associated with neutrophil functions were Elane and Mpo, the crucial granule proteins of neutrophils that mediate chronic inflammation. Our study demonstrated that neutrophil-specific Elane knockout reduced neutrophil infiltration into the brain parenchyma and alleviated neuroinflammation. Elane plays a critical role in modulating the influence of peripheral neutrophils on brain.
Published in
Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice
Mou R, Ma J, Ju X et al. · Cell stem cell 2024 · PMID 39442524 · doi:10.1016/j.stem.2024.09.018
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Also filed as BioProject PRJNA1132996 and SRA study SRP518534. Searching any of these in the dataset finder brings you back here.

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