GEO series
Impact of severe traumatic brain injury (TBI) on cerebral blood flow and the endothelial cell phenotype
GSE271769
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2024/12/02
GPL21626
Summary
TBI causes the disruption of blood vessels in brain leading to hemorrhage, edema, and changes in cerebral blood flow. How such altered vascular and flow condition affect endothelial cells, the cellular unit of blood vessels, is not known. We used single cell RNA sequencing (scRNAseq) to analyze the heterogenity in endothelial cell clusters in brain, and how key cellular and signaling signatures of these clusters are temporally changed post-TBI at the site of injury.
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Paper (PMID 39605741) ↗
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