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Hepatic transcriptome analysis of WT and PRDX1Cys52Ser mutant mice on CDAHFD

GSE271914 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/05 Platform GPL24247
Summary
In this study, we investigated how the peroxidase peroxiredoxin 1 protects against NASH. One previous study showed that PRDX1 cys52 was mutated to ser52 and consequently PRDX1’s peroxidase activity was impaired. Surprisingly, PRDX1Cys52Ser mice showed robust resistance to diet-induced NASH. To this end, We sought to understand how PRDX1Cys52Ser mutant confers resistance to NASH although impairing PRDX1’s peroxidase activity. We fed WT and PRDX1Cys52Ser mice a CDAHFD for 8 weeks and collected liver samples for RNA sequencing analysis. As revealed by gene-set enrichment analysis (GSEA) and KEGG pathway enrichment analysis, there was an enrichment of genes involved in inflammation, fiberosis and JAK-STAT signaling.
Published in
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice
Yin W, Xu H, Bai Z et al. · Nature communications 2025 · PMID 39799115 · doi:10.1038/s41467-025-55939-2
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Also filed as BioProject PRJNA1134115 and SRA study SRP519047. Searching any of these in the dataset finder brings you back here.

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