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Dysregulation of gene expression during gastrulation results in impaired primitive erythropoiesis and vascular development in Trim71-KO embryos

GSE272044 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/02/04 Platform GPL24247
Summary
During embryonic development in mice, global deficiency of Trim71 (Trim71-KO) leads to defects in vascular development of the yolk sac and impaired primitive erythropoiesis. These phenotypes start to become apparent at E9.5. We analyzed changes in gene expression by single-cell RNA-sequencing (scRNA-seq) in whole Trim71-KO embryos compared to wildtype embryos at an early developmental stage (E7.5, late gastrulation) to investigate the onset of these phenotypes. Furthermore, we analyzed Trim71-KO and wildtype yolk sacs at E9.5 by scRNA-seq to gain insight into the changes in gene expression at the developmental stage when vascular defects have become apparent.
Published in
Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos
Beckröge T, Jux B, Seifert H et al. · Life science alliance 2025 · PMID 39909558 · doi:10.26508/lsa.202402956
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Also filed as BioProject PRJNA1134743 and SRA study SRP519393. Searching any of these in the dataset finder brings you back here.

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