GEO series

Noncoding RNA, ncRNA-a3, epigenetically regulates TAL1 transcriptional program during erythropoiesis (NG Capture-C)

GSE272340 Homo sapiens (human) Other 3 samples Submitted 2025/05/07 Platform GPL24676

At a glance

human · 3 samples

Organism: Homo sapiens (human)
Samples: 3 samples
Data you can get: A processed table (series matrix) and supplementary files from NCBI.
Paper: Noncoding RNA, ncRNA-a3, Epigenetically Regulates TAL1 Transcriptional Program During ErythropoiesisMolecular and cellular biology · 2025

Summary (written by the submitters)

Here, we showed that a long non-coding RNA (lncRNA), ncRNA-a3 that is transcribed from TAL1 erythroid +51kb enhancer, is required for TAL1 activation during EPO-induced lineage commitment and formation of erythroblasts. ncRNA-a3 regulates long-range chromatin interactions between +51 enhancer, promoter and other regulatory elements in the TAL1 locus to maintain the erythroid interaction hub.

Read the full summary ↓

By binding and recruiting p300/BRG1 to the TAL1 locus ncRNA-a3 facilitates chromatin accessibility in the TAL1 locus and activates TAL1 transcription program, including subsequent epigenetic and transcriptional activation of erythroid specific TAL1 target genes.

Published in

Noncoding RNA, ncRNA-a3, Epigenetically Regulates TAL1 Transcriptional Program During Erythropoiesis

Matur M, Uzun Y, Shi X et al. · Molecular and cellular biology 2025 · PMID 40211453 · doi:10.1080/10985549.2025.2482079

This dataset

Open GSE272340 in finder → Find more human datasets →

Download · which file do I need?

Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE272340_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

Also filed as BioProject PRJNA1136481. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40211453) ↗

Samples in this study

The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.

+ 3 more — browse all 3 samples with per-sample file links →

Datasets on a similar topic

GSE272339 Noncoding RNA, ncRNA-a3, epigenetically regulates TAL1 transcriptional program during erythropoiesis (CUT&Run) 15 samples shares ncrna-a3, tal1, epigenetically, erythropoiesis, noncoding, program
GSE272341 Noncoding RNA, ncRNA-a3, epigenetically regulates TAL1 transcriptional program during erythropoiesis (RNA-Seq) 13 samples shares ncrna-a3, tal1, epigenetically, erythropoiesis, noncoding, program
GSE272338 Noncoding RNA, ncRNA-a3, epigenetically regulates TAL1 transcriptional program during erythropoiesis (ATAC-Seq) 3 samples shares ncrna-a3, tal1, epigenetically, erythropoiesis, noncoding, program
GSE305789 Activation of OSM-STAT3 Epigenetically Regulates Tumor-Promoting Transcriptional Programs in Cervical Cancer [RNA-Seq] 8 samples shares epigenetically, program
GSE305788 Activation of OSM-STAT3 Epigenetically Regulates Tumor-Promoting Transcriptional Programs in Cervical Cancer [ATAC-Seq] 8 samples shares epigenetically, program
GSE222296 Nuclear IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming 10 samples shares erythropoiesis, program
GSE241864 The SLC1A1/EAAT3 Dicarboxylic Amino Acid Transporter is an Epigenetically Dysregulated Nutrient Carrier that Sustains Oncogenic Metabolic Programs 8 samples shares epigenetically, program
GSE222401 Nuclear IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming 6 samples shares erythropoiesis, program

Search all human datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.