GEO series
The Tie-2 antagonist rebastinib reduces ovarian cancer growth in a syngeneic murine model
GSE272411
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/07/18
GPL24247
Summary
Background: The receptor tyrosine kinase TIE2 and its ligands, angiopoietins (ANGPTs), promote angiogenesis. In addition to expression on vascular endothelial cells, TIE2 is expressed on M2-like pro-tumorigenic macrophages. Thus, the TIE2 inhibitor rebastinib was developed as a potential therapy to address multiple cancers. The objective of this study was to determine the effects of rebastinib alone and combined with chemotherapy in a syngeneic murine model of ovarian cancer.
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Paper (PMID 39930466) ↗
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